Sprague Word

The future and more from Richard Sprague

Archive for November, 2005

Posted by sprague on November 26, 2005

Barron’s Online – Plugged In: “Palatin’s claim to future fame rests on a single, as yet unnamed drug, PT-141, an aerosol treatment for sexual dysfunction that could be approved by the FDA by early 2009. Unlike Pfizer’s (PFE) Viagra, Glaxo SmithKline’s (GSK) Levitra and Eli Lilly’s (LLY) Cialis, all of which target the vascular system in men, PT-141 works through the central nervous system, which means it probably will not be contra-indicated for men with high blood pressure or heart problems. But what really excites Semon and others, though they all stress it’s a big gamble, is PT-141’s apparent success in correcting female sexual dysfunction, a huge but hitherto totally untreated market.

‘The first real, honest-to-God, horny-making, body-shaking, equal-opportunity aphrodisiac,’ blared New York Magazine in a recent article. The story went on to quote women who said that, as soon as 15 minutes after sniffing the odorless PT-141 through an inhaler, they felt ‘genital warmth, tingling and throbbing,’ not to mention ‘a strong desire to have sex.'”

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Posted by sprague on November 15, 2005

Genes worsen effects of statin drugs: study – Yahoo! News


“This study is one piece of the overall equation that we and others are trying to fill in to understand why some people do not respond as well as others to statin therapy,” said Dr. Ronald Krauss, director of atherosclerosis research at Children’s Hospital Oakland Research Institute in California, who led the study.

For the study, Krauss and colleagues tested the DNA of 296 black Americans and 573 whites, all of them typical high cholesterol patients who would normally be prescribed statin drugs.

Krauss’ team found nine variations of the gene that carries the code for HMGCoA reductase, the enzyme that statin drugs target to reduce the body’s production of cholesterol.

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