Sprague Word

The future and more from Richard Sprague

Posted by sprague on November 15, 2005

Genes worsen effects of statin drugs: study – Yahoo! News


“This study is one piece of the overall equation that we and others are trying to fill in to understand why some people do not respond as well as others to statin therapy,” said Dr. Ronald Krauss, director of atherosclerosis research at Children’s Hospital Oakland Research Institute in California, who led the study.

For the study, Krauss and colleagues tested the DNA of 296 black Americans and 573 whites, all of them typical high cholesterol patients who would normally be prescribed statin drugs.

Krauss’ team found nine variations of the gene that carries the code for HMGCoA reductase, the enzyme that statin drugs target to reduce the body’s production of cholesterol.

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